Consensus Recommendations on Initiating Prescription Therapies for Opioid-Induced Constipation
نویسندگان
چکیده
منابع مشابه
Consensus Recommendations on Initiating Prescription Therapies for Opioid‐Induced Constipation
OBJECTIVE Aims of this consensus panel were to determine (1) an optimal symptom-based method for assessing opioid-induced constipation in clinical practice and (2) a threshold of symptom severity to prompt consideration of prescription therapy. METHODS A multidisciplinary panel of 10 experts with extensive knowledge/experience with opioid-associated adverse events convened to discuss the lite...
متن کاملOpioid Induced Constipation
The definitions of constipation include a reference to infrequent, difficult or incomplete bowel evacuation that may lead to pain and discomfort; with stools that can range from small, hard ’rocks’, to a large bulky mass. Constipation may be debilitating among those who require chronic analgesia (7); OIC or OBD affected an average of 41 % patients taking an oral opioid for up to 8 weeks in a me...
متن کاملDrugs in Development for Opioid-Induced Constipation
Opioid-induced bowel dysfunction (OIBD) is a collective term used to describe the gastrointestinal side effects of long-term opioid therapy in chronic pain patients. Constipation, nausea, vomiting, bloating, abdominal pain, and gastric reflux are among the most common gastrointestinal adverse effects. Within opioid-induced bowel dysfunction, a more specific subset exists, opioid-induced constip...
متن کاملMethylnaltrexone (Relistor) for opioid induced constipation.
www.aafp.org/afp Volume 82, Number 6 ◆ September 15, 2010 Methylnaltrexone (Relistor) is labeled for the treatment of opioid-induced constipation in patients with advanced illness who have not responded to laxative therapies.1 As a selective antagonist of peripheral mu-opioid receptors, methylnaltrexone inhibits opioidinduced gastrointestinal (GI) hypomotility without central nervous system eff...
متن کاملEmerging treatments in neurogastroenterology: a multidisciplinary working group consensus statement on opioid-induced constipation.
BACKGROUND Opioids are effective for acute and chronic pain conditions, but their use is associated with often difficult-to-manage constipation and other gastrointestinal (GI) effects due to effects on peripheral μ-opioid receptors in the gut. The mechanism of opioid-induced constipation (OIC) differs from that of functional constipation (FC), and OIC may not respond as well to most first-line ...
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ژورنال
عنوان ژورنال: Pain Medicine
سال: 2015
ISSN: 1526-2375,1526-4637
DOI: 10.1111/pme.12937